The possible double strike of Novel Coronavirus
Posted on 22 Sep 2020; 03:00 PM IST. Last Updated 24 Sep 2020; 07:30 PM IST.Summary: The Novel Coronavirus (Covid-19) is known to present many symptoms. Physicians take the clinical diagnosis route, while biologists tend to take molecular modeling route for explanations. Finally, biology is the driving force, which could provide and validate the clues, and insights. This article provides a tiny insight on how the Novel coronavirus could be rendering a double strike, by striking simultaneously, the ACE2 receptor and the AChE enzyme, which plays a critical role in the nervous system.
The Novel Coronavirus (Covid-19) is known to present many symptoms. The list of symptoms is long, and the elusive question is what to make out of these symptoms. Physicians take the clinical diagnosis route, while biologists tend to take Molecular modeling route for explanations.
From a simplistic view, the Novel Coronavirus appears like a "poison". Surprisingly, this view is not inconsistent with the clinical manifestation of the disease.
The author has accidentally stumbled upon a webpage related to "cholinesterase blood test" (which is used to determine poisoning), and noticed that "All the symptoms listed under cholinesterase test" match with Novel Coronavirus or covid-19.
In the inferential world of artificial intelligence (AI), it is possible to draw a conclusion that Novel Coronavirus appears like a "poison". Of course, we need to supply physical evidence, to make the conclusion stronger, and a useful hypothesis.
Recent articles on Novel Coronavirus state that it attacks the AChE enzyme, in addition to the ACE2 receptor. The author regards this invasion a double strike, a term (probably) coined by Dr. Carlo Brogna (reference-1).
The author does not believe in the synergy between the two mechanisms (AChE enzyme and ACE2 receptor) as proposed by Dr. Carlo Brogna, but suggests without evidence, that the Novel coronavirus could be simultaneously attacking both ACE2 receptor and the AChE enzyme.
From the biological knowledge base, we could note that when the AChE enzyme is attacked, it could disrupt the choline cycle and produce neurological symptoms consistent with poisoning.
This fact could serve as physical evidence, for the conclusion, that Novel Coronavirus appears like a "poison".
Finally, biology is the driving force, which could provide and validate the clues, and insights, and physicians and/or biologists must confirm or reject the hypothesis.
Conclusion
ACE2 receptor may not be the only factor affected by the Novel coronavirus. The author believes (without evidence), that the involvement of AChE enzyme could explain the sudden heart attacks in Covid-19 patients, on the ground that the term "sudden" is often related to neurological factors.
References
- Carlo Brogna;
The Covid-19 virus double pathogenic mechanism. A new perspective;
https://europepmc.org/article/ppr/ppr152737
- Naughton Sean, Raval Urdhvaa, Pasinetti Giulio;
Potential Novel Role of COVID-19 in Alzheimer’s Disease and Preventative Mitigation Strategies;
https://content.iospress.com/articles/journal-of-alzheimers-disease/jad200537